If you’re craving comfort food that’s bursting with cheesy, savory goodness, then this Cheesy Beef Tortellini Enchilada Casserole Recipe is going to become your new favorite go-to. Imagine tender cheese tortellini smothered in rich enchilada sauce, layered with perfectly browned beef, and topped with ooey-gooey melted mozzarella—the ultimate fusion of Italian pasta and Mexican flavors in one hearty, satisfying casserole. It’s quick to prepare but delivers big on taste and family-friendly appeal.

Ingredients You’ll Need
Gathering simple, flavorful ingredients is key to this recipe’s success. Each component plays a crucial role, from the cheesy tortellini providing a delightful tenderness to the spicy enchilada sauce that adds just the right kick and moisture, while the ground beef brings hearty protein and texture. And of course, the mozzarella cheese ensures everything melts together into a luscious, bubbly topping.
- Cheese tortellini (16 ounces): Choose fresh or refrigerated tortellini for the best texture and cheesy filling.
- Lean ground beef (1 pound): Using lean beef keeps the casserole rich without being greasy.
- Enchilada sauce (16 ounces): Pick your favorite brand or homemade version for authentic flavor and moisture.
- Shredded mozzarella cheese (2 cups): It melts beautifully and adds a stretchy, creamy finish.
- Fresh parsley, chopped (optional): Adds a pop of color and freshness when sprinkled on top.
How to Make Cheesy Beef Tortellini Enchilada Casserole Recipe
Step 1: Prepare the Tortellini
Start by preheating your oven to 350°F (175°C)—this ensures it’s ready for baking later. Meanwhile, cook the 16 ounces of cheese tortellini according to the package instructions until just al dente. Drain well and set aside; this step is crucial since you don’t want soggy pasta in your casserole, just perfectly tender sheets of cheesy goodness.
Step 2: Brown the Ground Beef
Place the lean ground beef in a skillet over medium heat and cook, breaking it up as it browns evenly. Cook until it’s no longer pink throughout and then drain off any excess grease. This part provides the savory base for your casserole—browned beef adds so much flavor and heartiness that complements the richness of the tortellini and enchilada sauce.
Step 3: Combine and Assemble the Casserole
In a 9×13 inch oven-safe casserole dish, mix together the cooked tortellini, browned beef, 16 ounces of enchilada sauce, and 1 cup of shredded mozzarella cheese. Toss everything gently so the sauce coats each pasta piece and beef morsel. Then sprinkle the remaining 1 cup of mozzarella evenly over the top. This layering results in gooey cheese both inside the casserole and on top for that irresistible crust.
Step 4: Bake to Perfection
Pop your assembled casserole into the oven and bake for 20 to 30 minutes, or until the cheese on top is melted, bubbly, and lightly golden. This baking step melds the flavors together and creates that deliciously inviting smell that fills your kitchen. Let it rest for a few minutes before serving to let everything set just right.
Step 5: Garnish and Serve
Once your Cheesy Beef Tortellini Enchilada Casserole Recipe is out of the oven, sprinkle it with freshly chopped parsley if you like a touch of green brightness. Serve warm and watch everyone dig into this hearty, cheesy masterpiece with smiles all around.
How to Serve Cheesy Beef Tortellini Enchilada Casserole Recipe

Garnishes
Fresh herbs like parsley or cilantro bring a lovely freshness that cuts through the richness. A dollop of sour cream or a sprinkle of sliced green onions also complements the cheesy beef flavors beautifully and adds an extra layer of creaminess or crunch.
Side Dishes
This casserole pairs nicely with simple sides like a crisp green salad or steamed veggies to balance the indulgence. For a heartier meal, consider charred corn on the cob or a side of refried beans to keep that Mexican-inspired theme going strong.
Creative Ways to Present
For a fun twist, serve individual portions in small ramekins topped with a pinch of extra cheese and a sprig of fresh herbs. You could also transform leftovers into stuffed bell peppers or wrap them in tortillas for quick, delicious enchilada-style lunches. The versatility of this Cheesy Beef Tortellini Enchilada Casserole Recipe means you can get creative beyond the traditional casserole dish.
Make Ahead and Storage
Storing Leftovers
This casserole keeps beautifully in the fridge for up to 4 days in an airtight container. Reheat portions in the microwave or oven for a quick and satisfying next-day meal without losing any of its cheesy, saucy goodness.
Freezing
You can freeze the casserole unbaked or after it’s cooked. To freeze before baking, cover tightly in plastic wrap and foil; then bake from frozen, adding extra baking time. If freezing after baking, cool completely before wrapping well. Frozen casseroles last about 2 to 3 months without losing flavor or texture.
Reheating
For the best texture, reheat leftovers in the oven at 350°F until warmed through and bubbly—not just in the microwave, which can make pasta rubbery. Cover the dish loosely with foil to prevent drying out while reheating.
FAQs
Can I use other types of pasta instead of tortellini?
Absolutely! While cheese tortellini gives this casserole its signature creamy pockets of cheese, feel free to swap in ravioli or even mini shells if that’s what you have on hand. Just cook them al dente before assembling.
Is it possible to make this recipe vegetarian?
Yes! Simply replace the ground beef with sautéed veggies like mushrooms, bell peppers, and zucchini or a plant-based ground meat alternative. The enchilada sauce and cheese will still provide plenty of flavor.
How spicy is the enchilada sauce used in this recipe?
The spice level depends on the brand of enchilada sauce you choose. For a milder casserole, pick a mild sauce, or bump up the heat with a spicy variety. You can also add some diced jalapeños for an extra kick.
Can I prepare this casserole in advance for a party?
Definitely! You can assemble everything the day before, cover tightly, and refrigerate. Then bake when you’re ready to serve for a fresh, hot dish that tastes like you made it from scratch that day.
What can I do if I want a crispier top on my casserole?
For a crispier cheese topping, switch to a mix of mozzarella and cheddar or sprinkle some panko breadcrumbs over the cheese before baking. Broil for the last 2-3 minutes to get a golden crust, but watch carefully to make sure it doesn’t burn.
Final Thoughts
If you want a meal that feels like a warm hug on a plate, full of cheesy, beefy goodness with a fun twist, this Cheesy Beef Tortellini Enchilada Casserole Recipe is the answer. It’s easy to make, satisfying, and perfect for busy weeknights or casual family gatherings. Once you try it, I’m sure you’ll want to keep this recipe in your regular rotation because comfort food doesn’t get much better than this.
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Cheesy Beef Tortellini Enchilada Casserole Recipe
- Prep Time: 5 minutes
- Cook Time: 30 minutes
- Total Time: 35 minutes
- Yield: 8 servings
- Category: Casserole
- Method: Baking
- Cuisine: Mexican-American
Description
This Cheesy Beef Tortellini Enchilada Casserole combines tender cheese tortellini with seasoned ground beef and rich enchilada sauce, all topped with melted mozzarella cheese for a comforting and flavorful baked dish perfect for weeknight dinners or family gatherings.
Ingredients
Main Ingredients
- 16 ounces cheese tortellini
- 1 pound lean ground beef
- 16 ounces enchilada sauce
- 2 cups shredded mozzarella cheese
- Fresh parsley, chopped (optional, for garnish)
Instructions
- Preheat and Cook Tortellini: Preheat the oven to 350°F (175°C). Cook the cheese tortellini according to the package directions until al dente, then drain and set aside.
- Brown the Ground Beef: In a skillet over medium heat, brown the lean ground beef until fully cooked through. Drain any excess grease to keep the dish from being greasy.
- Combine Ingredients and Assemble Casserole: In a 9×13 inch oven-safe casserole dish, combine the cooked tortellini, browned ground beef, enchilada sauce, and 1 cup of shredded mozzarella cheese. Toss everything thoroughly to coat evenly. Sprinkle the remaining mozzarella cheese on top of the mixture.
- Bake the Casserole: Place the casserole dish in the preheated oven and bake for 20-30 minutes until the cheese is melted, bubbly, and lightly golden.
- Garnish and Serve: Remove the casserole from the oven and garnish with chopped fresh parsley if desired. Serve warm and enjoy a delicious cheesy enchilada-inspired dinner.
Notes
- You can use homemade or store-bought enchilada sauce based on preference.
- For additional flavor, consider adding diced onions or garlic when browning the beef.
- To make it spicier, add a pinch of chili powder or jalapeños.
- Leftovers can be stored refrigerated for up to 3 days and reheated in the oven or microwave.
- Fresh parsley garnish is optional but adds a nice fresh touch and color contrast.

